Literature summary for 7.1.1.1 extracted from

Althage, M.; Bizouarn, T.; Kindlund, B.; Mullins, J.; Alander, J.; Rydstrom, J.
Cross-linking of transmembrane helices in proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli: implications for the structure and function of the membrane domain (2004), Biochim. Biophys. Acta, 1659, 73-82.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
E124C	domian dII, strongly reduced reverse activity, no effect on cyclic activity	Escherichia coli
G476C	domian dII, little effect on activity	Escherichia coli
S105C	domian dII, significantly reduced activity	Escherichia coli
S183C	domian dII, significantly reduced activity	Escherichia coli
S237C	domian dII, slightly reduced reverse activity, no efect on cyclic activity	Escherichia coli
S2C	domian dII, no effect on activity	Escherichia coli
T54C	domian dII, significantly reduced activity	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Escherichia coli	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NADH + NADP+	Escherichia coli	links hydride transfer between NAD(H) and NADP(H) to the outside in translocation of protons across membrane	NAD+ + NADPH	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADH + NADP+	-	Escherichia coli	NAD+ + NADPH	-	r
NADH + NADP+	links hydride transfer between NAD(H) and NADP(H) to the outside in translocation of protons across membrane	Escherichia coli	NAD+ + NADPH	-	r

Subunits

Subunits	Comment	Organism
dimer	monomers consist of three domains dI, dII, and dIII located on two separate polypeptide chains	Escherichia coli

Synonyms

Synonyms	Comment	Organism
proton-pumping nicotinamide nucleotide transhydrogenase	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
NAD(P)+	-	Escherichia coli
NAD(P)H	-	Escherichia coli

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Release 2023.1 (January 2023)