Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.1.1.1 extracted from

  • Mather, O.C.; Singh, A.; van Boxel, G.I.; White, S.A.; Jackson, J.B.
    Active-site conformational changes associated with hydride transfer in proton-translocating transhydrogenase (2004), Biochemistry, 43, 10952-10964.
    View publication on PubMed
Search for more literature for 7.1.1.1

Cloned(Commentary)

Cloned (Comment) Organism
dI and dIII domains separately expressed in Escherichia coli Rhodospirillum rubrum
dIII domain expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Rhodospirillum rubrum
dI2dIII complex with bound NAD+ and NADP+, NADH and NADPH, and ADP-ribose and NADPH Rhodospirillum rubrum
dIII domain in the presence of NADPH Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rhodospirillum rubrum 16020
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + NADP+ Rhodospirillum rubrum links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction NAD+ + NADPH
-
 r
NADH + NADP+ Homo sapiens links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction NAD+ + NADPH
-
 r
NADPH + NAD+ + H+[side 1] Rhodospirillum rubrum
-
 NADP+ + NADH + H+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13423
-
-
Rhodospirillum rubrum
-
-
-
Rhodospirillum rubrum Q2RSB2
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rhodospirillum rubrum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+
-
 Rhodospirillum rubrum NAD+ + NADPH
-
 r
NADH + NADP+
-
 Homo sapiens NAD+ + NADPH
-
 r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction Rhodospirillum rubrum NAD+ + NADPH
-
 r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction Homo sapiens NAD+ + NADPH
-
 r
NADPH + NAD+ + H+[side 1]
-
 Rhodospirillum rubrum NADP+ + NADH + H+[side 2]
-
 ?

Subunits

Subunits Comment Organism
dimer monomer composed of three domains dI, dII, and dIII Rhodospirillum rubrum
dimer monomer composed of three domains dI, dII, and dIII Homo sapiens

Synonyms

Synonyms Comment Organism
proton-translocating transhydrogenase
-
 Rhodospirillum rubrum

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
 Rhodospirillum rubrum
NAD(P)+
-
 Homo sapiens
NAD(P)H
-
 Rhodospirillum rubrum
NAD(P)H
-
 Homo sapiens