Literature summary for 6.5.1.8 extracted from

Nandy, A.; Saenz-Mendez, P.; Gorman, A.M.; Samali, A.; Eriksson, L.A.
Homology model of the human tRNA splicing ligase RtcB (2017), Proteins, 85, 1983-1993 .

Search for more literature for 6.5.1.8

Protein Variants

Protein Variants	Comment	Organism
C122A	the mutant does not bind Mn2+	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O	Homo sapiens	-	(ribonucleotide)n+m + GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y3I0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O	-	Homo sapiens	(ribonucleotide)n+m + GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
rtcB	-	Homo sapiens
tRNA splicing ligase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
GTP	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme operates during the unfolded protein response	Homo sapiens

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Release 2023.1 (January 2023)