Literature summary for 6.5.1.8 extracted from

Kosmaczewski, S.G.; Edwards, T.J.; Han, S.M.; Eckwahl, M.J.; Meyer, B.I.; Peach, S.; Hesselberth, J.R.; Wolin, S.L.; Hammarlund, M.
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response (2014), EMBO Rep., 15, 1278-1285.

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Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	P90838	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(ribonucleotide)n-3'-phosphate + 5'-hydroxy-(ribonucleotide)m + GTP	-	Caenorhabditis elegans	(ribonucleotide)n+m + GMP + diphosphate	overall reaction, RtcB is required for ligation of endogenous intron-containing pre-tRNAs	?

Synonyms

Synonyms	Comment	Organism
Rtcb-1	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	RtcB ligates the xbp-1 mRNA during the IRE-1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp-1 mRNA fragments, defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre-tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre-spliced tRNAs. Animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response	Caenorhabditis elegans

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Release 2023.1 (January 2023)