Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.5.1.8 extracted from

  • Poothong, J.; Tirasophon, W.; Kaufman, R.
    Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response (2017), Biosci. Rep., 37, BSR20160574.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.8

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Escherichia coli
expression in Saccharomyces cerevisiae Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens Q9Y3I0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
rtcB
-
 Escherichia coli
rtcB
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function upon ER stress, HAC1/XBP1 undergoes exon/intron-specific excision by inositol requiring enzyme 1 to remove an intron and liberate the 5' and 3' exons, which are ligated by tRNA ligase. Expression of RtcB alone in a Saccharomyces cerevisiae tRNA ligase mutant strain inefficiently complements HAC1/XBP1 splicing and the RtcB cofactor archease is required to promote enzymatic activity of RtcB to catalyse RNA ligation Homo sapiens
physiological function upon ER stress, HAC1/XBP1 undergoes exon/intron-specific excision by inositol requiring enzyme 1 to remove an intron and liberate the 5' and 3' exons, which are ligated by tRNA ligase. Expression of RtcB in a Saccharomyces cerevisiae tRNA ligase mutant strain is able to complement HAC1/XBP1 splicing Escherichia coli