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Literature summary for 6.5.1.2 extracted from

  • Pergolizzi, G.; Cominetti, M.M.; Butt, J.N.; Field, R.A.; Bowater, R.P.; Wagner, G.K.
    Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases (2015), Org. Biomol. Chem., 13, 6380-6398 .
    View publication on PubMed
Search for more literature for 6.5.1.2

Inhibitors

Inhibitors Comment Organism Structure
2-iodo-AMP
-
 Escherichia coli
2-iodo-AMP
-
 Mycobacterium tuberculosis
2-iodo-NAD+
-
 Escherichia coli
2-iodo-NAD+
-
 Mycobacterium tuberculosis
2-phenyl-NAD+
-
 Escherichia coli
2-phenyl-NAD+
-
 Mycobacterium tuberculosis
Quinacrine
-
 Escherichia coli
Quinacrine
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycobacterium tuberculosis
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycobacterium tuberculosis H37Rv
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Escherichia coli (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycobacterium tuberculosis (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycobacterium tuberculosis H37Rv (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Synonyms

Synonyms Comment Organism
NAD(+)-dependent DNA ligase
-
 Escherichia coli
NAD(+)-dependent DNA ligase
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Escherichia coli
NAD+
-
 Mycobacterium tuberculosis