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Literature summary for 6.5.1.2 extracted from

  • Konomura, N.; Arai, N.; Shinohara, T.; Kobayashi, J.; Iwasaki, W.; Ikawa, S.; Kusano, K.; Shibata, T.
    Rad51 and RecA juxtapose dsDNA ends ready for DNA ligase-catalyzed end-joining under recombinase-suppressive conditions (2017), Nucleic Acids Res., 45, 337-352 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Rad51 Rad51 enhances Escherichia coli DNA ligase-catalyzed DNA ligation to produce multimers in an ADP-dependent manner Escherichia coli
RecA when incubated with linear double stranded DNA with 3' four-nucleotide overhangs and ATP, RecA greatly accelerates the end-joining to form multimers of the double stranded DNA catalyzed by NAD-dependent Escherichia coli DNA ligase Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Escherichia coli (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?

Synonyms

Synonyms Comment Organism
NAD-dependent DNA ligase
-
Escherichia coli