Literature summary for 6.5.1.2 extracted from

Giroux, X.; MacNeill, S.A.
Inhibiting NAD+-dependent DNA ligase activity with 2-(cyclopentyloxy)-5'-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeon Haloferax volcanii (2015), FEMS Microbiol. Lett., 362, pii: fnv181 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(cyclopentyloxy)-5'-deoxyadenosine	-	Haloferax volcanii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m	Haloferax volcanii	-	(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide	-	?

Organism

Organism	UniProt	Comment	Textmining
Haloferax volcanii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m	-	Haloferax volcanii	(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide	-	?

Synonyms

Synonyms	Comment	Organism
LigN	-	Haloferax volcanii
NAD+-dependent DNA ligase	-	Haloferax volcanii

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Haloferax volcanii

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Release 2023.1 (January 2023)