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Literature summary for 6.5.1.2 extracted from

  • Stokes, S.S.; Huynh, H.; Gowravaram, M.; Albert, R.; Cavero-Tomas, M.; Chen, B.; Harang, J.; Loch, J.T.; Lu, M.; Mullen, G.B.; Zhao, S.; Liu, C.F.; Mills, S.D.
    Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity (2011), Bioorg. Med. Chem. Lett., 21, 4556-4560.
    View publication on PubMed
Search for more literature for 6.5.1.2

Cloned(Commentary)

Cloned (Comment) Organism
recombinantly expressed Staphylococcus aureus
recombinantly expressed Streptococcus pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
2-(butylsulfanyl)-5'-deoxyadenosine
-
 Staphylococcus aureus
2-(butylsulfanyl)-5'-deoxyadenosine
-
 Streptococcus pneumoniae
2-(butylsulfanyl)adenosine
-
 Staphylococcus aureus
2-(butylsulfanyl)adenosine
-
 Streptococcus pneumoniae
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
 Staphylococcus aureus
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
 Streptococcus pneumoniae
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
-
 Staphylococcus aureus
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
-
 Streptococcus pneumoniae
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
-
 Staphylococcus aureus
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
-
 Streptococcus pneumoniae
2-(pentyloxy)adenosine
-
 Staphylococcus aureus
2-(pentyloxy)adenosine
-
 Streptococcus pneumoniae
2-(pentylsulfanyl)adenosine
-
 Staphylococcus aureus
2-(pentylsulfanyl)adenosine
-
 Streptococcus pneumoniae
5'-deoxy-2-(pentyloxy)adenosine
-
 Staphylococcus aureus
5'-deoxy-2-(pentyloxy)adenosine
-
 Streptococcus pneumoniae
5'-deoxy-2-phenoxyadenosine
-
 Staphylococcus aureus
5'-deoxy-2-phenoxyadenosine
-
 Streptococcus pneumoniae
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
 Staphylococcus aureus
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
 Streptococcus pneumoniae
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
-
 Staphylococcus aureus
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
-
 Streptococcus pneumoniae
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
 Staphylococcus aureus
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
 Streptococcus pneumoniae
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
 Staphylococcus aureus
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
 Streptococcus pneumoniae
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
-
 Staphylococcus aureus
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
-
 Streptococcus pneumoniae
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
 Staphylococcus aureus
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
 Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Streptococcus pneumoniae
-
-
-

Synonyms

Synonyms Comment Organism
LigA
-
 Staphylococcus aureus
LigA
-
 Streptococcus pneumoniae
NAD+-dependent DNA ligase
-
 Staphylococcus aureus
NAD+-dependent DNA ligase
-
 Streptococcus pneumoniae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
0.00002
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
0.00003
-
 pH and temperature not specified in the publication Staphylococcus aureus 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
0.00004
-
 pH and temperature not specified in the publication Staphylococcus aureus 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
0.00004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
0.00005
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
0.00005
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
0.00006
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
0.00007
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
0.00008
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(butylsulfanyl)adenosine
0.00008
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-2-(pentyloxy)adenosine
0.00008
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
0.00009
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
0.00011
-
 pH and temperature not specified in the publication Staphylococcus aureus 9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
0.00012
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
0.00012
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
0.00012
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-2-(pentyloxy)adenosine
0.00013
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
0.00013
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(butylsulfanyl)-5'-deoxyadenosine
0.00014
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(butylsulfanyl)adenosine
0.00014
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-2-phenoxyadenosine
0.00015
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(pentyloxy)adenosine
0.00016
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
0.00017
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(butylsulfanyl)-5'-deoxyadenosine
0.00037
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
0.00038
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(pentylsulfanyl)adenosine
0.0004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
0.00043
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(pentyloxy)adenosine
0.00044
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(pentylsulfanyl)adenosine
0.00267
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-2-phenoxyadenosine