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Literature summary for 6.5.1.2 extracted from

  • Gong, C.; Martins, A.; Bongiorno, P.; Glickman, M.; Shuman, S.
    Biochemical and genetic analysis of the four DNA ligases of mycobacteria (2004), J. Biol. Chem., 279, 20594-20606.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
produced in Escherichia coli as a His10-LigA fusion Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
pyridochromanone IC50: 0.0006 mM Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0013
-
NAD+
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m Mycobacterium tuberculosis LigA is essential for growth of Mycobacterium tuberculosis AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His10-LigA fusion Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Mycobacterium tuberculosis AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m LigA is essential for growth of Mycobacterium tuberculosis Mycobacterium tuberculosis AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
?

Subunits

Subunits Comment Organism
monomer
-
Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
LigA
-
Mycobacterium tuberculosis
MtuLigA
-
Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.072
-
NAD+
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0006
-
IC50: 0.0006 mM Mycobacterium tuberculosis pyridochromanone