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Literature summary for 6.5.1.1 extracted from

  • Pawlowska, R.; Korczynski, D.; Nawrot, B.; Stec, W.J.; Chworos, A.
    The alpha-thio and/or beta-gamma-hypophosphate analogs of ATP as cofactors of T4 DNA ligase (2016), Bioorg. Chem., 67, 110-115 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by adenosine-5'-O-(P2,P3-hypo-P1-oxo)-triphosphate and adenosine-5'-O-(P2,P3-hypo-P1-thio)-triphosphate Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Tequatrovirus T4
-
(deoxyribonucleotide)n+m + AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Tequatrovirus T4 (deoxyribonucleotide)n+m + AMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
ATP-dependent DNA ligase
-
Tequatrovirus T4
T4 DNA ligase
-
Tequatrovirus T4

Cofactor

Cofactor Comment Organism Structure
ATP
-
Tequatrovirus T4
additional information adenosine-5'-O-(P2,P3-hypo-P1-oxo)-triphosphate and adenosine-5'-O-(P2,P3-hypo-P1-thio)-triphosphate are efficient cofactors Tequatrovirus T4