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Literature summary for 6.5.1.1 extracted from

  • Sillero, M.A.G.; Montes, M.; de Diego, A.; del Valle, M.; Atencia, E.A.; Sillero, A.
    Thermostable Pyrococcus furiosus DNA ligase catalyzes the synthesis of (di)nucleoside polyphosphates (2002), Extremophiles, 6, 45-50.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
molecular biology the enzyme is used in the ligase chain reaction Pyrococcus furiosus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
ATP pH 7.5, 70°C, synthesis of P1-(5'-adenosyl),P4-(5'-guanosyl)tetraphosphate Pyrococcus furiosus
0.4
-
GTP pH 7.5, 70°C, synthesis of P1-(5'-adenosyl),P4-(5'-guanosyl)tetraphosphate Pyrococcus furiosus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ optimal concentration: 4 mM Pyrococcus furiosus

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus P56709
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ADP
-
Pyrococcus furiosus P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate + diphosphate
-
?
ATP + CDP
-
Pyrococcus furiosus P1-(5'-adenosyl),P3-(5'-cytidyl)triphosphate + diphosphate
-
?
ATP + CTP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-(5'-cytidyl)tetraphosphate + diphosphate
-
?
ATP + dCTP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-[5'-(2'-deoxycytidyl)]tetraphosphate + diphosphate
-
?
ATP + dGTP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-[5'-(2'-deoxyguanosyl)]tetraphosphate + diphosphate
-
?
ATP + dTTP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-(5'-thymidyl)tetraphosphate + diphosphate
-
?
ATP + GDP
-
Pyrococcus furiosus P1-(5'-adenosyl),P3-(5'-guanosyl)triphosphate + diphosphate
-
?
ATP + GTP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-(5'-guanosyl)tetraphosphate + diphosphate
-
?
ATP + UTP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-(5'-uridinyl)tetraphosphate + diphosphate
-
?
ATP + XDP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-(5'-xanthosyl)tetraphosphate + diphosphate
-
?
ATP + XTP
-
Pyrococcus furiosus P1-(5'-adenosyl),P4-(5'-xanthosyl)tetraphosphate + diphosphate
-
?
additional information the rate of synthesis of Ap4N is double that of the corresponding Ap3N Pyrococcus furiosus ?
-
?

Synonyms

Synonyms Comment Organism
DNA ligase
-
Pyrococcus furiosus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
-
Pyrococcus furiosus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.5
-
Pyrococcus furiosus