Literature summary for 6.5.1.1 extracted from

Cherepanov, A.V.; Doroshenko, E.V.; Matysik, J.; de Vries, S.; de Groot, H.J.
The associative nature of adenylyl transfer catalyzed by T4 DNA ligase (2008), Proc. Natl. Acad. Sci. USA, 105, 8563-8568.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required for activity	Tequatrovirus T4

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	in the first step of catalysis, DNA ligase binds ATP, forming a high-energy covalent enzyme-nucleotide complex. Nucleophilic attack on the alpha-phosphorus of ATP results in cleavage of the triphosphate moiety, formation of the enzyme-AMP epsilon-amino lysyl phosphoramidate, and release of the diphosphate	Tequatrovirus T4	AMP + diphosphate + (deoxyribonucleotide)m+n	-	r

Synonyms

Synonyms	Comment	Organism
T4 DNA ligase	-	Tequatrovirus T4

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Tequatrovirus T4

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Release 2023.1 (January 2023)