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Literature summary for 6.5.1.1 extracted from

  • Buguliskis, J.S.; Casta, L.J.; Butz, C.E.; Matsumoto, Y.; Taraschi, T.F.
    Expression and biochemical characterization of Plasmodium falciparum DNA ligase I (2007), Mol. Biochem. Parasitol., 155, 128-137.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
KCl 30 mM, more than 60% reduction in product formation Plasmodium falciparum
NaCl above 20 mM, more than 60% reduction in product formation Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000026
-
nicked DNA 37°C, pH 8.5 Plasmodium falciparum

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ enzyme can utilize Ca2+ as cofactor Plasmodium falciparum
Mg2+ maximal activation at 0.6 mM Plasmodium falciparum
Mn2+ maximal activation at 6 mM Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m PfLigI is able to join RNA-DNA substrates only when the RNA sequence is upstream of the nick. Slight activity with dATP. No activity with NAD+, UTP, CTP and GTP. Slight activity with dATP. No activity with NAD+, UTP, CTP or GTP Plasmodium falciparum AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
ATP + nicked DNA
-
Plasmodium falciparum AMP + diphosphate + ?
-
?

Synonyms

Synonyms Comment Organism
DNA ligase I
-
Plasmodium falciparum
PfLigI
-
Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Plasmodium falciparum

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 40 about 50% of maximal activity at 25°C and at 40°C Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0023
-
nicked DNA 37°C, pH 8.5 Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Plasmodium falciparum

pH Range

pH Minimum pH Maximum Comment Organism
7.5 9.5 pH 7.5: about 40% of maximal activity, pH 9.5: about 40% of maximal activity Plasmodium falciparum