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Literature summary for 6.5.1.1 extracted from

  • Marchetti, C.; Walker, S.A.; Odreman, F.; Vindigni, A.; Doherty, A.J.; Jeggo, P.
    Identification of a novel motif in DNA ligases exemplified by DNA ligase IV (2006), DNA Repair, 5, 788-798.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant Xrcc4/DNA ligase IV complexes in insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G468A mutant enzyme shows residual adenylate complex formation at high protein concentrations, mutant complex has a lower affinity for ATP compared to wild-type complex Homo sapiens
G468E mutant DNA ligase IV/Xrrc4 complex is poorly expressed, mutation completely abolishes adenylate complex formation, mutant complex has no ligation activity Homo sapiens
G469A mutant enzyme shows residual adenylate complex formation Homo sapiens
G469E mutant DNA ligase IV/Xrrc4 complex is poorly expressed, mutation completely abolishes adenylate complex formation, mutant complex has no ligation activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
wild-type and mutant DNA ligase IV/Xrrc4 complexes Homo sapiens

Synonyms

Synonyms Comment Organism
DNA ligase IV
-
Homo sapiens