Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant Xrcc4/DNA ligase IV complexes in insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G468A | mutant enzyme shows residual adenylate complex formation at high protein concentrations, mutant complex has a lower affinity for ATP compared to wild-type complex | Homo sapiens |
G468E | mutant DNA ligase IV/Xrrc4 complex is poorly expressed, mutation completely abolishes adenylate complex formation, mutant complex has no ligation activity | Homo sapiens |
G469A | mutant enzyme shows residual adenylate complex formation | Homo sapiens |
G469E | mutant DNA ligase IV/Xrrc4 complex is poorly expressed, mutation completely abolishes adenylate complex formation, mutant complex has no ligation activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
wild-type and mutant DNA ligase IV/Xrrc4 complexes | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DNA ligase IV | - |
Homo sapiens |