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Literature summary for 6.5.1.1 extracted from

  • Tomkinson, A.E.; Vijayakumar, S.; Pascal, J.M.; Ellenberger, T.
    DNA ligases: Structure, reaction mechanism, and function (2006), Chem. Rev., 106, 687-699.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of human DNA ligase I bound to nicked, 5'-adenylated DNA. The crystal structure of human DNA ligase I complexed to DNA demonstrates that the enzyme encircles its DNA substrate Homo sapiens

General Stability

General Stability Organism
DNA ligase IV depends on the partner protein XRCC4 for stability and activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens detection and characterization of a direct physical interaction between DNA ligase I, proliferating cell nuclear antigen, a DNA sliding clamp, and, more recently, an interaction between DNA ligase I and replication factor C, the sliding clamp loader AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens mitochondrial DNA ligase IIIalpha is critical for the mitochondrial function, role of DNA ligase IIIbeta in gametogenesis AMP + diphosphate + (deoxyribonucleotide)n+m
-
?

Organism

Organism UniProt Comment Textmining
Escherichia phage T7 P00969
-
-
Homo sapiens P18858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m detection and characterization of a direct physical interaction between DNA ligase I, proliferating cell nuclear antigen, a DNA sliding clamp, and, more recently, an interaction between DNA ligase I and replication factor C, the sliding clamp loader Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m mitochondrial DNA ligase IIIalpha is critical for the mitochondrial function, role of DNA ligase IIIbeta in gametogenesis Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
additional information the ATP-dependent DNA ligase from bacteriophage T7 is a two-domain ligase: the adenylation or nucleotide-binding domain binds ATP and is connected to an OB-fold domain by a flexible linker. The ATP-binding pocket within the amino-terminal domain of bacteriophage T7 is formed by two antiparallel beta-sheets flanked by R-helices Escherichia phage T7 ?
-
?

Synonyms

Synonyms Comment Organism
ATP-dependent DNA ligase
-
Escherichia phage T7
DNA ligase I
-
Homo sapiens
DNA ligase III
-
Homo sapiens
DNA ligase IV
-
Homo sapiens