Literature summary for 6.5.1.1 extracted from

Goetz, J.D.; Motycka, T.A.; Han, M.; Jasin, M.; Tomkinson, A.E.
Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line (2005), DNA Repair, 4, 649-654.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	Homo sapiens	the ability of DNA ligase I to promote the recombinational repair of DNA double-strand breaks is dependent upon its interaction with proliferating cell nuclear antigen. DNA ligase I-deficiency reduces recombinational repair of DNA double-strand breaks	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	the ability of DNA ligase I to promote the recombinational repair of DNA double-strand breaks is dependent upon its interaction with proliferating cell nuclear antigen. DNA ligase I-deficiency reduces recombinational repair of DNA double-strand breaks	Homo sapiens	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?

Synonyms

Synonyms	Comment	Organism
DNA ligase I	-	Homo sapiens

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Release 2023.1 (January 2023)