Activating Compound | Comment | Organism | Structure |
---|---|---|---|
spermidine | 5 mM, increases the Km for nicked DNA, increases reaction velocity | Bos taurus | |
spermine | 0.5 mM, increases the Km for nicked DNA, increases reaction velocity | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dATP | competitive with respect to ATP | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00011 | - |
DNA | nicked DNA 5'-phosphoryl ends | Bos taurus | |
0.002 | - |
ATP | ATP | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Bos taurus | |
Mg2+ | optimal concentration: 10 mM | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calf | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate | uni-uni uni-bi ping-pong mechanism. The order of substrate addition and product release is as follows: ATP, diphosphate, nicked DNA, sealed DNA, 5'-AMP | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymus | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Bos taurus | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? | |
ATP + DNA | - |
Bos taurus | AMP + diphosphate + ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.117 | - |
DNA | - |
Bos taurus |