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Literature summary for 6.4.1.7 extracted from
- A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6 (2004), Mol. Microbiol., 51, 791-798.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Hydrogenobacter thermophilus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Avidin | - |
Hydrogenobacter thermophilus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Hydrogenobacter thermophilus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 49000 | - |
x * 72000 + x * 49000, likely subunit structure alpha8beta8, SDS-PAGE | Hydrogenobacter thermophilus |
| 72000 | - |
x * 72000 + x * 49000, likely subunit structure alpha8beta8, SDS-PAGE | Hydrogenobacter thermophilus |
| 998000 | - |
gel filtration | Hydrogenobacter thermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 2-oxoglutarate + HCO3- | Hydrogenobacter thermophilus | - |
ADP + phosphate + oxalosuccinate | - |
? | |
| ATP + 2-oxoglutarate + HCO3- | Hydrogenobacter thermophilus TK-6 / IAM 12695 | - |
ADP + phosphate + oxalosuccinate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hydrogenobacter thermophilus | - |
TK-6 | - |
| Hydrogenobacter thermophilus TK-6 / IAM 12695 | - |
TK-6 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Hydrogenobacter thermophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 2-oxoglutarate + HCO3- | - |
Hydrogenobacter thermophilus | ADP + phosphate + oxalosuccinate | - |
? | |
| ATP + 2-oxoglutarate + HCO3- | - |
Hydrogenobacter thermophilus TK-6 / IAM 12695 | ADP + phosphate + oxalosuccinate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 72000 + x * 49000, likely subunit structure alpha8beta8, SDS-PAGE | Hydrogenobacter thermophilus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxylating factor for ICDH | incorrect | Hydrogenobacter thermophilus |
| CFI | - |
Hydrogenobacter thermophilus |
| OGC | - |
Hydrogenobacter thermophilus |
| oxalosuccinate synthetase | - |
Hydrogenobacter thermophilus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| biotin | enzyme contains biotin | Hydrogenobacter thermophilus | |
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Release 2023.1 (January 2023)
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