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Literature summary for 6.4.1.4 extracted from

  • Ding, G.; Che, P.; Ilarslan, H.; Wurtele, E.S.; Nikolau, B.J.
    Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination (2012), Plant J., 70, 562-577.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures diffracted to 1.5 A resolution of the Pseudomonas aeruginosa MCC (PaMCC) holoenzyme are shown, alone and in complex with coenzyme A. The structures show that the architecture and overall shape of PaMCC are strikingly different when compared to propionyl-CoA carboxylase Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q42523
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Arabidopsis thaliana Q9LDD8
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Synonyms

Synonyms Comment Organism
MCCA gene name for MCCA subunit of MCCAase Arabidopsis thaliana
MCCase
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Arabidopsis thaliana
MCCB gene name for MCCB subunit of MCCAase Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction T-DNA and transposon-tagged mutant alleles of the MCCA and MCCB genes of Arabidopsis thaliana are recovered. Mutations in either MCCA or MCCB block mitochondrial Leu catabolism. Under light deprivation conditions, the hyper-accumulation of Leu, 3-methylcrotonyl CoA and isovaleryl CoA indicates that mitochondrial and peroxisomal Leu catabolism pathways are independently regulated. Block in mitochondrial Leu catabolism is associated with an impaired reproductive growth phenotype. The decreased seed germination phenotype is only observed for homozygous mutant seeds Arabidopsis thaliana