Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Caenorhabditis elegans | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | Q19842 and Q20676 | Q19842 i.e. subunit PccA-1, Q20676 i.e. subunit PccB-1 | - |
Synonyms | Comment | Organism |
---|---|---|
PccA-1 | - |
Caenorhabditis elegans |
PccB-1 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | animal lifespan is significantly reduced relative to wild-type worms in mutant strains lacking either subunit PccA or PccB. Mitochondrial oxidative phosphorylation capacity and efficiency of isolated mitochondria are also significantly reduced in both mutant strains. In vivo quantitation of mitochondrial physiology is normal in PccB-1 mutants, but PccA-1 deletion mutants have significantly increased mitochondrial matrix oxidant burden as well as significantly decreased mitochondrial membrane potential and mitochondrial content. Both deletion strains have decreased accumulation of malate, isotopic enrichment in citrate, and increased lactate accumulation | Caenorhabditis elegans |