Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells at 27°C and 37°C | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A497V | beta subunit, no effect on subunit interactions and activity | Homo sapiens |
DELTA531 | beta subunit, strongly affects subunit interactions, very low activity | Homo sapiens |
E168K | beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C | Homo sapiens |
G131R | beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C | Homo sapiens |
G198D | beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C) reduced activity at 37°C | Homo sapiens |
L519P | beta subunit, strongly affects subunit interactions, very low activity | Homo sapiens |
N536D | beta subunit, strongly affects subunit interactions, very low activity | Homo sapiens |
R165Q | beta subunit, no effect on subunit interactions and activity | Homo sapiens |
R165W | beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C | Homo sapiens |
R512C | beta subunit, strongly affects subunit interactions, very low activity | Homo sapiens |
R67S | beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C | Homo sapiens |
S106R | beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + propanoyl-CoA + HCO3- | Homo sapiens | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + propanoyl-CoA + HCO3- | - |
Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? | |
ATP + propanoyl-CoA + HCO3- | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
dodecamer | 6 alpha and 6 beta subunits | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
biotin | bound to enzyme | Homo sapiens |