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Literature summary for 6.4.1.3 extracted from

  • Rodriguez, E.; Gramajo, H.
    Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2) (1999), Microbiology, 145, 3109-3119.
No PubMed abstract available
Search for more literature for 6.4.1.3

Cloned(Commentary)

Cloned (Comment) Organism
subunits individually cloned and expressed in Escherichia coli DH5alpha Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + propanoyl-CoA + HCO3- Streptomyces coelicolor important for polyketide and fatty acid synthesis ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
-
 strains M145, MA4 and MTC21
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + propanoyl-CoA + HCO3-
-
 Streptomyces coelicolor ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
ATP + propanoyl-CoA + HCO3- important for polyketide and fatty acid synthesis Streptomyces coelicolor ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?

Subunits

Subunits Comment Organism
multimer biotin carboxylase (alpha-subunit) and carboxyl transferase (beta-subunit) Streptomyces coelicolor

Cofactor

Cofactor Comment Organism Structure
biotin bound to alpha subunit of the enzyme Streptomyces coelicolor