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Literature summary for 6.4.1.2 extracted from

  • Glatzel, D.K.; Koeberle, A.; Pein, H.; Loeser, K.; Stark, A.; Keksel, N.; Werz, O.; Mueller, R.; Bischoff, I.; Fuerst, R.
    Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition (2018), J. Lipid Res., 59, 298-311 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
soraphen A inhibitor reduces the levels of malonyl-CoA in endothelial cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13085
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell ACC1 is the predominant isoform in human umbilical vein endothelial cells as well as in human microvascular endothelial cells Homo sapiens
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General Information

General Information Comment Organism
physiological function inhibition of Acc1 in endotheial cells shifts the lipid composition of membranes. Membrane fluidity, filopodia formation, and migratory capacity are reduced. The antimigratory action of inhibition depends on an increase in the cellular proportion of polyunsaturated fatty acids and on a decreased level of phosphatidylglycerol Homo sapiens