Inhibitors | Comment | Organism | Structure |
---|---|---|---|
soraphen A | inhibitor reduces the levels of malonyl-CoA in endothelial cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13085 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | ACC1 is the predominant isoform in human umbilical vein endothelial cells as well as in human microvascular endothelial cells | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | inhibition of Acc1 in endotheial cells shifts the lipid composition of membranes. Membrane fluidity, filopodia formation, and migratory capacity are reduced. The antimigratory action of inhibition depends on an increase in the cellular proportion of polyunsaturated fatty acids and on a decreased level of phosphatidylglycerol | Homo sapiens |