Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.4.1.2 extracted from

  • Bourrellier, A.; Valot, B.; Guillot, A.; Ambard-Bretteville, F.; Vidal, J.; Hodges, M.
    Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit (2010), Proc. Natl. Acad. Sci. USA, 107, 502-507.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.4.1.2

Inhibitors

Inhibitors Comment Organism Structure
Avidin general inhibitor of ACCase activity Arabidopsis thaliana
fenoxaprop a specific inhibitor of the cytosolic ACCase, does not affect the activity of chloroplast ACCase Arabidopsis thaliana
PII protein recombinant Arabidopsis PII protein inhibits chloroplastic ACCase activity dose-dependently and noncompetitively via binding to its BCCP subunit, and this is completely reversed in the presence of 2-oxoglutarate, pyruvate, or oxaloacetate. PII protein decreases the Vmax of the ACCase reaction without altering the Km for acetyl-CoA Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-
cytosol
-
 Arabidopsis thaliana 5829
-
plastid
-
 Arabidopsis thaliana 9536
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Arabidopsis thaliana ADP + malonyl-CoA + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ACCase
-
 Arabidopsis thaliana
BCCP1 ACCase subunit Arabidopsis thaliana
BCCP2 ACCase subunit Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana
biotin
-
 Arabidopsis thaliana

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00015
-
 apparent value, in 100 mM Tricine (pH 8.2), at 30°C Arabidopsis thaliana PII protein

General Information

General Information Comment Organism
physiological function ACCase is a key enzyme initiating the synthesis of fatty acids in plastids Arabidopsis thaliana