Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Trypanosoma brucei | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Trypanosoma brucei | ADP + malonyl-CoA + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * about 200000, SDS-PAGE | Trypanosoma brucei |
? | x * about 243000, estimated from amino acid sequence | Trypanosoma brucei |
Synonyms | Comment | Organism |
---|---|---|
ACC | - |
Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Trypanosoma brucei | |
biotin | - |
Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
malfunction | in procyclic forms, ACC RNAi results in 50-75% reduction in fatty acid elongation and a 64% reduction in growth in low-lipid media. In bloodstream forms, ACC RNAi results in a minor 15% decrease in fatty acid elongation and no growth defect in culture, even in low-lipid media. ACC RNAi does attenuate virulence in a mouse model of infection | Trypanosoma brucei |
metabolism | ACC is required for elongation of fatty acids, both laurate and myristate are elongated to products up to 18 carbons | Trypanosoma brucei |
physiological function | ACC is required by procyclic forms for growth in culture under lipid-limited conditions and by bloodstream forms for full virulence in mice | Trypanosoma brucei |