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Literature summary for 6.4.1.2 extracted from

  • Bengtsson, C.; Blaho, S.; Saitton, D.B.; Brickmann, K.; Broddefalk, J.; Davidsson, O.; Drmota, T.; Folmer, R.; Hallberg, K.; Hallen, S.; et al.
    Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats (2011), Bioorg. Med. Chem., 19, 3039-3053.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
Homo sapiens
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
Rattus norvegicus
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]-methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
Homo sapiens
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
Rattus norvegicus
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
Homo sapiens
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
Rattus norvegicus
CP-640186
-
Homo sapiens
CP-640186
-
Rattus norvegicus
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclo-hexyl]-methyl]carbamate
-
Rattus norvegicus
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
-
Rattus norvegicus
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
Homo sapiens
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
-
Rattus norvegicus
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
Homo sapiens
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
Homo sapiens
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]-methyl]cyclohexyl)methyl]carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)methyl]-carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]-carbamate
-
Homo sapiens
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)-methyl]carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
-
Homo sapiens
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]-cyclohexyl)methyl]carbamate
-
Rattus norvegicus
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
-
Homo sapiens
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclo-hexyl]methyl]carbamate acetate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]-methyl]carbamate
-
Rattus norvegicus
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]-methyl]carbamate
-
Homo sapiens
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]-methyl)cyclohexyl]methyl]carbamate
-
Rattus norvegicus
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
Homo sapiens
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
Homo sapiens
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
Rattus norvegicus
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
Homo sapiens
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
Rattus norvegicus
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
obese Zucker rat
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Homo sapiens ADP + malonyl-CoA + phosphate
-
?
ATP + acetyl-CoA + HCO3-
-
Rattus norvegicus ADP + malonyl-CoA + phosphate
-
?

Synonyms

Synonyms Comment Organism
ACC
-
Rattus norvegicus
ACC1 or ACACA, isoform Homo sapiens
ACC2 or ACACB, isoform Homo sapiens
acetyl-CoA carboxylase 1
-
Homo sapiens
acetyl-CoA carboxylase 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
biotin
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000052
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.000089
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.000099
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
0.00011
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00013
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens 2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00021
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.00021
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
0.00023
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00024
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00024
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00033
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
0.00057
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
0.00063
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00068
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.00069
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00069
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00073
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00075
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens 4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
0.00078
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00078
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
0.001
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
0.001
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens 2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.001
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.0011
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.0012
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.0013
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.0013
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.0014
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.0017
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
0.0017
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens [trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
0.0023
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
0.0023
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0025
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0029
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens 4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
0.0029
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
0.0036
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens [4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
0.0038
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.0043
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0045
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.0045
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0053
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0058
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
0.0063
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.0066
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
0.008
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.0083
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
0.0099
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens [trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
0.01
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.013
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C Homo sapiens tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate