Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one | - |
Homo sapiens | |
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one | - |
Rattus norvegicus | |
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]-methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid | - |
Homo sapiens | |
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid | - |
Rattus norvegicus | |
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile | - |
Homo sapiens | |
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile | - |
Rattus norvegicus | |
CP-640186 | - |
Homo sapiens | |
CP-640186 | - |
Rattus norvegicus | |
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclo-hexyl]-methyl]carbamate | - |
Rattus norvegicus | |
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate | - |
Rattus norvegicus | |
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate | - |
Homo sapiens | |
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate | - |
Rattus norvegicus | |
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate | - |
Homo sapiens | |
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl]methyl)carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]-methyl]cyclohexyl)methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)methyl]-carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]-carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)-methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate | - |
Homo sapiens | |
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]-cyclohexyl)methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclo-hexyl]methyl]carbamate acetate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]-methyl]carbamate | - |
Rattus norvegicus | |
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]-methyl]carbamate | - |
Homo sapiens | |
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]-methyl)cyclohexyl]methyl]carbamate | - |
Rattus norvegicus | |
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | - |
Homo sapiens | |
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone | - |
Homo sapiens | |
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone | - |
Rattus norvegicus | |
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate | - |
Homo sapiens | |
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate | - |
Rattus norvegicus | |
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
obese Zucker rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Homo sapiens | ADP + malonyl-CoA + phosphate | - |
? | |
ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + malonyl-CoA + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACC | - |
Rattus norvegicus |
ACC1 | or ACACA, isoform | Homo sapiens |
ACC2 | or ACACB, isoform | Homo sapiens |
acetyl-CoA carboxylase 1 | - |
Homo sapiens |
acetyl-CoA carboxylase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
biotin | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000052 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.000089 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.000099 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate | |
0.00011 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.00013 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | 2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.00021 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | |
0.00021 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate | |
0.00023 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.00024 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.00024 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.00033 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate | |
0.00057 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate | |
0.00063 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.00068 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | |
0.00069 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.00069 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.00073 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.00075 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | 4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid | |
0.00078 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.00078 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate | |
0.001 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate | |
0.001 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | 2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.001 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | |
0.0011 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.0012 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.0013 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.0013 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.0014 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | |
0.0017 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate | |
0.0017 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | [trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate | |
0.0023 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate | |
0.0023 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.0025 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.0029 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | 4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid | |
0.0029 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate | |
0.0036 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | [4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone | |
0.0038 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | |
0.0043 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.0045 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.0045 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.0053 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.0058 | - |
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate | |
0.0063 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate | |
0.0066 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate | |
0.008 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | |
0.0083 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate | |
0.0099 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | [trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate | |
0.01 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate | |
0.013 | - |
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C | Homo sapiens | tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate |