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Literature summary for 6.4.1.2 extracted from

  • Chen, C.H.; Chang, M.Y.; Lin, Y.S.; Lin, D.G.; Chen, S.W.; Chao, P.M.
    A herbal extract with acetyl-coenzyme A carboxylase inhibitory activity and its potential for treating metabolic syndrome (2009), Metab. Clin. Exp., 58, 1297-1305.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-(tetradecyloxy)-2-furoic acid a hypolipidemic agent Rattus norvegicus
5-(tetradecyloxy)-2-furoyl-CoA
-
Rattus norvegicus
additional information an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, effectively reduces ACC and fatty acid synthase activity and the triacylglycerol content of HepG2 cells, overview Homo sapiens
additional information an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview Mus musculus
additional information an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC in liver microsomes with IC50 = 0.03 mg/ml. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus
Mg2+
-
Homo sapiens
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Mus musculus
-
ADP + phosphate + malonyl-CoA
-
ir
ATP + acetyl-CoA + HCO3- Homo sapiens
-
ADP + phosphate + malonyl-CoA
-
ir
ATP + acetyl-CoA + HCO3- Rattus norvegicus
-
ADP + phosphate + malonyl-CoA
-
ir
ATP + acetyl-CoA + HCO3- Mus musculus C57/BL6J
-
ADP + phosphate + malonyl-CoA
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
C57BL/6J mice
-
Mus musculus C57/BL6J
-
C57BL/6J mice
-
Rattus norvegicus
-
male Wistar rats
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from liver by two steps of ammonium sulfate fractionation, and anion exchange chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
26.93
-
purified native enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Mus musculus ADP + phosphate + malonyl-CoA
-
ir
ATP + acetyl-CoA + HCO3-
-
Homo sapiens ADP + phosphate + malonyl-CoA
-
ir
ATP + acetyl-CoA + HCO3-
-
Rattus norvegicus ADP + phosphate + malonyl-CoA
-
ir
ATP + acetyl-CoA + HCO3-
-
Mus musculus C57/BL6J ADP + phosphate + malonyl-CoA
-
ir

Synonyms

Synonyms Comment Organism
ACC
-
Mus musculus
ACC
-
Homo sapiens
ACC
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
pH 7.5, 37°C, partially purified native enzyme Rattus norvegicus 5-(tetradecyloxy)-2-furoyl-CoA

Expression

Organism Comment Expression
Homo sapiens high glucose concentration induces the enzyme up