Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(tetradecyloxy)-2-furoic acid | a hypolipidemic agent | Rattus norvegicus | |
5-(tetradecyloxy)-2-furoyl-CoA | - |
Rattus norvegicus | |
additional information | an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, effectively reduces ACC and fatty acid synthase activity and the triacylglycerol content of HepG2 cells, overview | Homo sapiens | |
additional information | an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview | Mus musculus | |
additional information | an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC in liver microsomes with IC50 = 0.03 mg/ml. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Mus musculus | - |
ADP + phosphate + malonyl-CoA | - |
ir | |
ATP + acetyl-CoA + HCO3- | Homo sapiens | - |
ADP + phosphate + malonyl-CoA | - |
ir | |
ATP + acetyl-CoA + HCO3- | Rattus norvegicus | - |
ADP + phosphate + malonyl-CoA | - |
ir | |
ATP + acetyl-CoA + HCO3- | Mus musculus C57/BL6J | - |
ADP + phosphate + malonyl-CoA | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Rattus norvegicus | - |
male Wistar rats | - |
Purification (Comment) | Organism |
---|---|
native enzyme from liver by two steps of ammonium sulfate fractionation, and anion exchange chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
26.93 | - |
purified native enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Mus musculus | ADP + phosphate + malonyl-CoA | - |
ir | |
ATP + acetyl-CoA + HCO3- | - |
Homo sapiens | ADP + phosphate + malonyl-CoA | - |
ir | |
ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
ir | |
ATP + acetyl-CoA + HCO3- | - |
Mus musculus C57/BL6J | ADP + phosphate + malonyl-CoA | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
ACC | - |
Mus musculus |
ACC | - |
Homo sapiens |
ACC | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0011 | - |
pH 7.5, 37°C, partially purified native enzyme | Rattus norvegicus | 5-(tetradecyloxy)-2-furoyl-CoA |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | high glucose concentration induces the enzyme | up |