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Literature summary for 6.4.1.2 extracted from
- Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats (2008), Life Sci., 82, 1262-1271.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| citrate | an intermediate metabolite, activates hypothalamic ACC and is involved in the control of energy mobilization | Rattus norvegicus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | Rattus norvegicus | intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview | ADP + phosphate + malonyl-CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar Hannover rats | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | ACC is inactivated by phosphorylation through AMP-activated protein kinase, AMPK, citrate treatment inhibits 75% of control hypothalamic AMPK phosphorylation during fasting, overview | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hypothalamus | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
| ATP + acetyl-CoA + HCO3- | intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview | Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACC | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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