Application | Comment | Organism |
---|---|---|
medicine | possible use of ACC inhibitors for diabetes therapy | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of the enzyme by siRNA transfected into the INS-1-derived cell line 832/13 affects insulin secretion, the enzyme activity in 832/13 cells and islets is reduced by 46-80% compared to the untreated cells, and glucose-stimulated insulin secretion is reduced by 70% in 832/13 cells and by 33% in islets, phenotypes, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(tetradecyloxy)-2-furoic acid | an ACC1 inhibitor e.g. in beta cells | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Rattus norvegicus | - |
ADP + phosphate + malonyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P11497 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastrocnemius | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
additional information | ACC1 and ACC2 tissue expression pattern, overview | Rattus norvegicus | - |
pancreatic beta cell | - |
Rattus norvegicus | - |
pancreatic islet | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACC1 | - |
Rattus norvegicus |
acetyl-CoA carboxylase 1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |