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Literature summary for 6.4.1.2 extracted from

  • Ronnebaum, S.M.; Joseph, J.W.; Ilkayeva, O.; Burgess, S.C.; Lu, D.; Becker, T.C.; Sherry, A.D.; Newgard, C.B.
    Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism (2008), J. Biol. Chem., 283, 14248-14256.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine possible use of ACC inhibitors for diabetes therapy Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information downregulation of the enzyme by siRNA transfected into the INS-1-derived cell line 832/13 affects insulin secretion, the enzyme activity in 832/13 cells and islets is reduced by 46-80% compared to the untreated cells, and glucose-stimulated insulin secretion is reduced by 70% in 832/13 cells and by 33% in islets, phenotypes, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
5-(tetradecyloxy)-2-furoic acid an ACC1 inhibitor e.g. in beta cells Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Rattus norvegicus
-
ADP + phosphate + malonyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P11497
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastrocnemius
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
additional information ACC1 and ACC2 tissue expression pattern, overview Rattus norvegicus
-
pancreatic beta cell
-
Rattus norvegicus
-
pancreatic islet
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Rattus norvegicus ADP + phosphate + malonyl-CoA
-
?

Synonyms

Synonyms Comment Organism
ACC1
-
Rattus norvegicus
acetyl-CoA carboxylase 1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus