Activating Compound | Comment | Organism | Structure |
---|---|---|---|
biotin | dependent on | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-6-morpholin-4-yl-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | 7% inhibition at 0.01 mM | Mus musculus | |
1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | 16% inhibition at 0.01 mM | Mus musculus | |
1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | 51% inhibition at 0.005 mM | Mus musculus | |
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine | i.e. CP-640186 or bispiperidylcarboxamide derivative I with a tricyclic hydrophobic core, shows inhibition of both ACC1 and ACC2 | Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one | 44% inhibition at 0.01 mM | Mus musculus | |
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-(1H-1,2,4-triazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one | complete inhibition at 0.005 mM | Mus musculus | |
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-[(1-methyl-1H-pyrazol-5-yl)amino]spiro[chromene-2,4'-piperidin]-4(3H)-one | complete inhibition at 0.005 mM | Mus musculus | |
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
6-morpholin-4-yl-1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | 64% inhibition at 0.01 mM | Mus musculus | |
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | - |
Mus musculus | |
additional information | synthesis of spiro[chroman-2,4-piperidin]-4-one derivatives as ACC inhibitors, overview | Mus musculus | |
N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide | - |
Mus musculus | |
N-[1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide | 4% inhibition at 0.01 mM | Mus musculus | |
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-N-methylbutanamide | 83% inhibition at 0.01 mM | Mus musculus | |
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide | - |
Mus musculus | |
N-[4-oxo-1'-(10H-phenothiazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide | 48% inhibition at 0.01 mM | Mus musculus | |
N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide | - |
Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Mus musculus | ACC plays an important role in energy balance by controlling malonyl-CoA synthesis | ADP + phosphate + malonyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J mice, isozymes ACC1 and ACC2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Mus musculus | ADP + phosphate + malonyl-CoA | - |
? | |
ATP + acetyl-CoA + HCO3- | ACC plays an important role in energy balance by controlling malonyl-CoA synthesis | Mus musculus | ADP + phosphate + malonyl-CoA | - |
? | |
additional information | structure-activity relationship, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structure-activity relationship, overview | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
ACC | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000006 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000006 | - |
- |
Mus musculus | N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide | |
0.000014 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000026 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000027 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000036 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000055 | - |
ACC1 and ACC2 | Mus musculus | 1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine | |
0.000059 | - |
- |
Mus musculus | 7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000061 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one | |
0.000061 | - |
- |
Mus musculus | N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide | |
0.000099 | - |
- |
Mus musculus | 6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | |
0.000101 | - |
- |
Mus musculus | N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide | |
0.000208 | - |
- |
Mus musculus | 7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | |
0.000236 | - |
- |
Mus musculus | 6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one | |
0.0012 | - |
- |
Mus musculus | 1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one |