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Literature summary for 6.4.1.2 extracted from

  • Shukla, A.; Nycholat, C.; Subramanian, M.V.; Anderson, R.J.; Devine, M.D.
    Use of resistant ACCase mutants to screen for novel inhibitors against resistant and susceptible forms of ACCase from grass weeds (2004), J. Agric. Food Chem., 52, 5144-5150.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype Eleusine indica
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype Setaria viridis
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype Eleusine indica
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype Setaria viridis
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype Eleusine indica
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype Setaria viridis
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype Eleusine indica
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype Setaria viridis
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype Eleusine indica
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype Setaria viridis
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype Eleusine indica
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype Setaria viridis
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype Eleusine indica
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype Setaria viridis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Setaria viridis
Mg2+
-
Eleusine indica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Setaria viridis
-
ADP + malonyl-CoA + phosphate
-
?
ATP + acetyl-CoA + HCO3- Eleusine indica
-
ADP + malonyl-CoA + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Eleusine indica
-
herbicide-sensitive and herbicide-resistant biotypes
-
Setaria viridis
-
herbicide-sensitive and herbicide-resistant biotypes
-

Purification (Commentary)

Purification (Comment) Organism
partially from young leaves by ammonium sulfate fractionation Setaria viridis
partially from young leaves by ammonium sulfate fractionation Eleusine indica

Source Tissue

Source Tissue Comment Organism Textmining
leaf young Setaria viridis
-
leaf young Eleusine indica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Setaria viridis ADP + malonyl-CoA + phosphate
-
?
ATP + acetyl-CoA + HCO3-
-
Eleusine indica ADP + malonyl-CoA + phosphate
-
?

Synonyms

Synonyms Comment Organism
ACCase
-
Setaria viridis
ACCase
-
Eleusine indica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
32
-
assay at Setaria viridis
32
-
assay at Eleusine indica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
assay at Setaria viridis
8.3
-
assay at Eleusine indica

Cofactor

Cofactor Comment Organism Structure
ATP
-
Setaria viridis
ATP
-
Eleusine indica

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0009
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype Setaria viridis 5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
0.0018
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype Setaria viridis 5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
0.0025
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype Setaria viridis 2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.0035
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype Setaria viridis 3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
0.0035
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype Setaria viridis 5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.0043
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype Eleusine indica 5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.0046
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype Eleusine indica 5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
0.0057
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype Eleusine indica 2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.017
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype Eleusine indica 3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
0.028
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype Eleusine indica 5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
0.038
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype Eleusine indica 2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
0.051
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype Setaria viridis 2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
0.054
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype Setaria viridis 2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
0.076
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype Eleusine indica 2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione