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Literature summary for 6.4.1.2 extracted from

  • Tomas, E.; Tsao, T.S.; Saha, A.K.; Murrey, H.E.; Zhang Cc, C.; Itani, S.I.; Lodish, H.F.; Ruderman, N.B.
    Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation (2002), Proc. Natl. Acad. Sci. USA, 99, 16309-16313.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Rattus norvegicus key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Sprangue-Dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein AMP-activated protein kinase phosphorylates and inactivates enzyme activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Rattus norvegicus ADP + phosphate + malonyl-CoA
-
?
ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Rattus norvegicus ADP + phosphate + malonyl-CoA
-
?

Cofactor

Cofactor Comment Organism Structure
biotin enzyme-bound Rattus norvegicus