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Literature summary for 6.4.1.2 extracted from
- A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis (2002), J. Biol. Chem., 277, 16347-16350.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chloroacetylated biotin derivative | 80% inhibition | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | Mus musculus | key enzyme of fatty acid biosynthesis | ADP + phosphate + malonyl-CoA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Mus musculus | ADP + phosphate + malonyl-CoA | - |
? | |
| ATP + acetyl-CoA + HCO3- | key enzyme of fatty acid biosynthesis | Mus musculus | ADP + phosphate + malonyl-CoA | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| biotin | enzyme-bound | Mus musculus | |
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