Literature summary for 6.4.1.2 extracted from

Atkinson, L.L.; Kelly, S.E.; Russell, J.C.; Bar-Tana, J.; Lopaschuk, G.D.
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats (2002), Diabetes, 51, 1548-1555.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	3,3,14,14-tetramethylhexanedecadienoic acid treatment if animals inhibits activity in liver by activation of AMP-activated protein kinase, no effect in muscle	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + acetyl-CoA + HCO3-	Rattus norvegicus	key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation	ADP + phosphate + malonyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	insulin resistant strain JCR:LA-cp and wild type rats	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	AMP-activated protein kinase phosphorylates and inactivates enzyme activity in liver	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	no differences in activity in muscle	Rattus norvegicus
0.00033	-	wild type rat liver, 37°C	Rattus norvegicus
0.00875	-	JCR:LA-cp rat liver, 37°C	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + acetyl-CoA + HCO3-	-	Rattus norvegicus	ADP + phosphate + malonyl-CoA	-	?
ATP + acetyl-CoA + HCO3-	key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation	Rattus norvegicus	ADP + phosphate + malonyl-CoA	-	?

Cofactor

Cofactor	Comment	Organism	Structure
biotin	enzyme-bound	Rattus norvegicus

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Release 2023.1 (January 2023)