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Literature summary for 6.4.1.2 extracted from
- Purification and characterization of acyl-CoA carboxylase from the goose uropygial gland which produces multimethyl-branched acids and evidence for its identity with avian acetyl-CoA carboxylase (1982), Arch. Biochem. Biophys., 213, 372-383.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| citrate | maximal stimulation at 20 mM, 3fold | Anser anser |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid | - |
Anser anser | |
| Cl- | - |
Anser anser | |
| Mg2+ | about 10 mM Mg2+ required for maximal activity, inhibition above 15 mM | Anser anser | |
| Na+ | - |
Anser anser | |
| Phenylglyoxal | - |
Anser anser | |
| pyridoxal 5'-phosphate | acetyl-CoA protects | Anser anser | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
ATP | propionyl-CoA | Anser anser | |
| 0.142 | - |
acetyl-CoA | - |
Anser anser | |
| 0.143 | - |
butyryl-CoA | - |
Anser anser | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | about 10 mM Mg2+ required for maximal activity, inhibition above 15 mM | Anser anser | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 238000 | - |
x * 238000, SDS-PAGE | Anser anser |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anser anser | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Anser anser |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uropygial gland | - |
Anser anser | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5 | - |
- |
Anser anser |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Anser anser | ADP + phosphate + malonyl-CoA | - |
? | |
| ATP + butyryl-CoA + HCO3- | - |
Anser anser | ADP + ethylmalonyl-CoA + phosphate | - |
? | |
| ATP + propionyl-CoA + HCO3- | - |
Anser anser | ADP + phosphate + methylmalonyl-CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 238000, SDS-PAGE | Anser anser |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Anser anser |
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