Literature summary for 6.4.1.1 extracted from

Phannasil, P.; Thuwajit, C.; Warnnissorn, M.; Wallace, J.; MacDonald, M.; Jitrapakdee, S.
Pyruvate carboxylase is up-regulated in breast cancer and essential to support growth and invasion of MDA-MB-231 cells (2015), PLoS ONE, 10, e0129848 .

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Application

Application	Comment	Organism
medicine	pyruvate carboxylase is expressed in the cancerous areas of breast tissue at higher levels than in the non-cancerous areas. There is a statistical association between the levels of pyruvate carboxylase expression and tumor size and tumor stage. The abundance of both pyruvate carboxylase mRNA and protein in MDA-MB-231 and MDA-MB-435 cells is 2-3fold higher than that in MCF-7 and SKBR-3 cells. siRNA-mediated knockdown of expression in MDA-MB-231 and MDA-MB-435 cells results in a 50% reduction of cell proliferation, migration and in vitro invasion ability, under both glutamine-dependent and glutamine-depleted conditions. Overexpression of pyruvate carboxylase in MCF-7 cells results in a 2fold increase in their proliferation rate, migration and invasion abilities	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11498	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
MDA-MB-435 cell	-	Homo sapiens	-
SKBR-3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)