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Literature summary for 6.4.1.1 extracted from

  • Songserm, P.; Thitiprasert, S.; Tolieng, V.; Piluk, J.; Tanasupawat, S.; Assabumrungrat, S.; Yang, S.T.; Karnchanatat, A.; Thongchul, N.
    Regulating pyruvate carboxylase in the living culture of Aspergillus terreus Nrrl 1960 by L-aspartate for enhanced itaconic acid production (2015), Appl. Biochem. Biotechnol., 177, 595-609 .
    View publication on PubMed

Application

Application Comment Organism
synthesis the presence of 10 mM L-aspartate in the production medium directly represses pyruvate carboxylase expression. This leads to limited malate flux which in turn regulates the malate/citrate antiporters resulting in increasing cis-aconitate decarboxylase activity to simultaneously convert cis-aconitate, citrate isomer, into itaconic acid Aspergillus terreus

Inhibitors

Inhibitors Comment Organism Structure
L-aspartate allosteric inhibitor Aspergillus terreus

Organism

Organism UniProt Comment Textmining
Aspergillus terreus
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Aspergillus terreus Nrrl 1960
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