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Literature summary for 6.4.1.1 extracted from
- Engineering the alpha-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP(+)-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica (2014), Appl. Microbiol. Biotechnol., 98, 2003-2013.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Yarrowia lipolytica | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pyc1 | - |
Yarrowia lipolytica |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | simultaneous overexpression of isocitrate dehydrogenase (IDP1) and pyruvate carboxylase (PYC) gene PYC1 increase the amount of secreted alpha-ketoglutaric acid. About 19% more alpha-ketoglutaric acid in comparison with the control strain H355 are produced in bioreactor with raw glycerol as carbon source resulting in the highest yield of accumulated alpha-ketoglutaric acid of about 186 g/L after 117 h of cultivation | Yarrowia lipolytica |
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