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Literature summary for 6.4.1.1 extracted from
- Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice (2010), J. Endocrinol., 204, 143-152.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in mildly hyperglycemic type 2 diabetic Agouti-K mice, islet pyruvate carboxylase activity, but not protein level, is increased 1.7fold. In severely hyperglycemic type 2 diabetic Agouti-K mice, islet pyruvate carboxylase activity and protein level are reduced. all other changes including insulin secretion and islet morphology in diabetic Agouti K mice are similar to those of obese Agouti mice | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
type 2 diabetic Agouti-K mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic islet | - |
Mus musculus | - |
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Release 2023.1 (January 2023)
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