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Literature summary for 6.3.5.5 extracted from

  • Weerasinghe, S.V.; Jang, Y.J.; Fontana, R.J.; Omary, M.B.
    Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury (2014), Am. J. Physiol. Gastrointest. Liver Physiol., 307, G355-G364 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.5.5

Application

Application Comment Organism
medicine serum samples from patients with acute liver failure due to acetaminophen, Wilson disease, or ischemia show readily detectable CPS1 that i not observed in patients with chronic viral hepatitis or in control donors. CPS1 rapidly decreases to undetectable levels in sera of patients with acetaminophen-related acute liver failure who ultimately recover Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
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mitochondrion
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 Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary mouse hepatocytes release CPS1 during Fas ligand-induced apoptotic injury, and CPS1 is detected in hepatocytes upon hypoosmotic stress Mus musculus
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additional information not detected in ductal cells Mus musculus
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serum CPS1 is detected in mouse serum upon acute challenge with Fas-ligand or acetaminophen, or in sera of mice chronically fed the hepatotoxin 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Half-life in serum is about 126 min Mus musculus
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serum serum samples from patients with acute liver failure due to acetaminophen, Wilson disease, or ischemia show readily detectable CPS1 that i not observed in patients with chronic viral hepatitis or in control donors. CPS1 rapidly decreases to undetectable levels in sera of patients with acetaminophen-related acute liver failure who ultimately recover Homo sapiens
-

Synonyms

Synonyms Comment Organism
CPS1
-
 Mus musculus
CPS1
-
 Homo sapiens