Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-ornithine | - |
Escherichia coli | |
potassium | - |
Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
in presence of both IMP and ornithine, structural analysis of the nucleotide monophosphate allosteric binding site for enzyme | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | IMP binds to enzyme but the actual effect of this ligand is dependent upon temperature and assay conditions | Escherichia coli | |
UMP | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + L-Gln + HCO3- + H+ + H2O | Escherichia coli | the product carbamoyl phosphate is utilized in the pyrimidine and arginine biosynthetic pathways | 2 ADP + phosphate + L-glutamate + carbamoyl phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + L-Gln + HCO3- | - |
Escherichia coli | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
2 ATP + L-Gln + HCO3- + H+ + H2O | the product carbamoyl phosphate is utilized in the pyrimidine and arginine biosynthetic pathways | Escherichia coli | 2 ADP + phosphate + L-glutamate + carbamoyl phosphate | - |
? | |
2 ATP + NH4+ + HCO3- | - |
Escherichia coli | 2 ADP + phosphate + carbamoyl phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | alpha,beta, that readly coverts to an tetrameric species: 4 * alpha, beta in presence of positive allosteric effectors | Escherichia coli |