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Literature summary for 6.3.5.5 extracted from

  • Thoden, J.B.; Huang, X.; Raushel, F.M.; Holden, H.M.
    The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway (1999), Biochemistry, 38, 16158-16166.
    View publication on PubMed
Search for more literature for 6.3.5.5

Protein Variants

Protein Variants Comment Organism
C269S mutant is unable to hydrolyse glutamine, the mutant is proved to be an adequate mimic for studies of the Michaelis complex Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + L-Gln + HCO3- Escherichia coli the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis 2 ADP + phosphate + L-Glu + carbamoyl phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Reaction

Reaction Comment Organism Reaction ID
2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate steps of reaction pathway for glutamine hydrolysis, the Michalis complex, the tetrahedral intermediate and glutamyl-thioester intermediate models, stereochemistry of the overall glutaminase reaction Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
 Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
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 ?
2 ATP + L-Gln + HCO3- the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
2 ATP + NH4+ + HCO3-
-
 Escherichia coli 2 ADP + phosphate + carbamoyl phosphate
-
 ?