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Literature summary for 6.3.5.5 extracted from

  • Ingraham, J.L.; Abdelal, A.T.H.
    Carbamoyl-phosphate synthetase (glutamine): Salmonella (1978), Methods Enzymol., 51, 29-35.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
5-phospho-alpha-D-ribosyl 1-diphosphate stimulates Salmonella enterica subsp. enterica serovar Typhimurium
Orn activates Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

Inhibitors Comment Organism Structure
UMP
-
Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
1 * 45000, beta, + 1 * 110000, alpha Salmonella enterica subsp. enterica serovar Typhimurium
110000
-
1 * 45000, beta, + 1 * 110000, alpha Salmonella enterica subsp. enterica serovar Typhimurium
150000
-
-
Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-Gln + HCO3- Salmonella enterica subsp. enterica serovar Typhimurium catalyzes the synthesis of all carbamoyl phosphate which serves two metabolic functions: it is an intermediate in synthesis of arginine and in the synthesis of pyrimidines ?
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Salmonella enterica subsp. enterica serovar Typhimurium
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.166
-
-
Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
Salmonella enterica subsp. enterica serovar Typhimurium 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
ATP + L-Gln + HCO3- catalyzes the synthesis of all carbamoyl phosphate which serves two metabolic functions: it is an intermediate in synthesis of arginine and in the synthesis of pyrimidines Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?

Subunits

Subunits Comment Organism
dimer 1 * 45000, beta, + 1 * 110000, alpha Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6 8.5 Gln-dependent activity Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
IMP stimulates Salmonella enterica subsp. enterica serovar Typhimurium