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Literature summary for 6.3.5.5 extracted from

  • Meek, T.D.; Karsten, W.E.; DeBrosse, C.W.
    Carbamoyl-phosphate synthetase II of the mammalian CAD protein: kinetic mechanism and elucidation of reaction intermediates by positional isotope exchange (1987), Biochemistry, 26, 2584-2593.
    View publication on PubMed
Search for more literature for 6.3.5.5

Inhibitors

Inhibitors Comment Organism Structure
Carbamoyl phosphate
-
 Mesocricetus auratus
L-Glu
-
 Mesocricetus auratus
MgATP2- product inhibition Mesocricetus auratus
phosphate
-
 Mesocricetus auratus

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
 Syrian hamster
-

Reaction

Reaction Comment Organism Reaction ID
2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate partially random sequential mechanism in which the ordered addition of MgATP2- , HCO3-, and Gln is followed by the ordered release of Glu and phosphate. The formation of carbamate from MgATP2-, HCO3-, and Gln proceeds via a stepwise, not concerted mechanism, involving at least one kinetically competent covalent intermediate, such as carboxyphosphate Mesocricetus auratus
a

Source Tissue

Source Tissue Comment Organism Textmining
BHK 165-23 cell SV40-transformed Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
 Mesocricetus auratus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
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