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Literature summary for 6.3.5.4 extracted from
- Glutamine-dependent asparagine synthetase in fetal, adult and neoplastic rat tissues (1975), Enzyme, 19, 314-328.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme from fetal liver extracts is significantly inhibited when combined with adult liver or tumor extracts | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.31 | - |
L-Asp | - |
Rattus norvegicus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | divalent metal ion required, Mg2+ more effective than Mn2+ | Rattus norvegicus | |
| Mn2+ | 10% of the activity relative to Mg2+ | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | low | Rattus norvegicus | - |
| breast cancer cell line | carcinoma | Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | high activity in fetal liver and low activity in adult liver | Rattus norvegicus | - |
| LLC-WRC 256 cell | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| McA-RH7777 cell | - |
Rattus norvegicus | - |
| ovary | - |
Rattus norvegicus | - |
| pancreas | adult pancreas is the most active tissue found | Rattus norvegicus | - |
| small intestine | low | Rattus norvegicus | - |
| spleen | low | Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Asp + L-Gln | - |
Rattus norvegicus | AMP + diphosphate + Asn + Glu | - |
? | |
| ATP + L-Asp + NH3 | 85% of the activity relative to Gln | Rattus norvegicus | AMP + diphosphate + Asn | - |
? | |
| additional information | ATP-diphosphate exchange reaction | Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.5 | minor variation of activity in this pH range | Rattus norvegicus |
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Release 2023.1 (January 2023)
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