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Literature summary for 6.3.5.4 extracted from
- Studies on the mechanism of the glutamine-dependent reaction catalyzed by asparagine synthetase from mouse pancreas (1980), J. Biol. Chem., 255, 1862-1866.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | noncompetitive versus ATP; poor inhibitor | Mus musculus |  |
| Asn | - |
Mus musculus | |
| diphosphate | competitive versus ATP | Mus musculus | |
| Glu | poor inhibitor; product inhibition | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate | hybrid uni uni bi ter ping pong Theorell-Chance mechanism where the glutaminase reaction occurs first and Asp binds to the enzyme before ATP in the sequential segment. Diphosphate is the first product released in the Theorell-Chance reaction, which is followed by the ordered release of AMP and Asn | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Asp + L-Gln | - |
Mus musculus | AMP + diphosphate + Asn + Glu | - |
? | |
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