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Literature summary for 6.3.5.3 extracted from

  • Chu, S.Y.; Henderson, J.F.
    Kinetic studies of phosphoribosyl-formylglycinamidine synthetase (1972), Can. J. Biochem., 50, 490-500.
    View publication on PubMed
Search for more literature for 6.3.5.3

Inhibitors

Inhibitors Comment Organism Structure
Glu noncompetitive with respect to Gln, competitive with respect to ATP, uncompetitive with respect to 5'-phosphoribosylformylglycinamide Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
 Gln 5'-phosphoribosylformylglycinamide Mus musculus
1.5
-
 ATP ATP Mus musculus
7.5
-
 NH4+
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate ping-pong mechanism Mus musculus
a
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate Gln binds to the free enzyme and Glu is released before the addition of ATP. ADP is released, and phosphoribosyl-formylglycinamide then binds. The liberation of phosphate is rapid, and 5'-phosphoribosylformylglycinamidine is the last product released Mus musculus
a

Source Tissue

Source Tissue Comment Organism Textmining
Ehrlich ascites carcinoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O
-
 Mus musculus ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu
-
 ?
ATP + 5'-phosphoribosylformylglycinamide + NH4+ + H2O
-
 Mus musculus ADP + phosphate + 5'-phosphoribosylformylglycinamidine
-
 ?