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Literature summary for 6.3.5.3 extracted from

  • Elliott, W.L.; Weber, G.
    Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (1984), Cancer Res., 44, 2430-2434.
    View publication on PubMed
Search for more literature for 6.3.5.3

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
 L-Gln liver and hepatoma 3924A Rattus norvegicus
0.06
-
 5'-phosphoribosylformylglycinamide liver and hepatoma 3924A Rattus norvegicus
1.5
-
 ATP liver and hepatoma 3924A Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
colon
-
 Rattus norvegicus
-
colonic carcinoma cell
-
 Homo sapiens
-
heart
-
 Rattus norvegicus
-
hepatoma cell 16, 20, 44, 7787, 7777, 3924A, 5123tc Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-
additional information increased activity in replicating cells and in tumors Homo sapiens
-
additional information increased activity in replicating cells and in tumors Rattus norvegicus
-
renal cell carcinoma cell
-
 Homo sapiens
-
renal cortex
-
 Rattus norvegicus
-
skeletal muscle
-
 Rattus norvegicus
-
small intestine
-
 Rattus norvegicus
-
spleen
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-
thymus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O
-
 Homo sapiens ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu
-
 ?
ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O
-
 Rattus norvegicus ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 liver and hepatoma 3924A Rattus norvegicus