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Literature summary for 6.3.5.2 extracted from

  • McConkey, G.A.
    Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase (2000), Exp. Parasitol., 94, 23-32.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a viable target for development of antimalarial chemotherapy Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
isolation of the gene Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
Psicofuranine
-
Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum GMP is necessary for DNA and RNA synthesis. Expression of the gene encoding GMP synthase coincides with the points in the life cycle with increased DNA and RNA synthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q9U775
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GMP is necessary for DNA and RNA synthesis. Expression of the gene encoding GMP synthase coincides with the points in the life cycle with increased DNA and RNA synthesis Plasmodium falciparum ?
-
?